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Kenneth offit lab 0 × 10 −8), 15 of which showed evidence for associations with at least one tumor feature (false discovery rate (FDR) <0. Kenneth Offit, Catherine M Sharkey, Dina View the Kenneth Offit Lab page for Bryan Devolder. D. Candidates with a research background and recent Masters Degree are preferred; Biology or Bioinformatics majors with at least an undergraduate degree View the Kenneth Offit Lab page for Danylko Villano. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an I am a medical oncologist with clinical and laboratory experience in cancer genetics. We are seeking a highly motivated and experienced Functional Postdoctoral Fellow/ Senior Research Scientist in the field of functional genomics to join our research team. Verified email at mskcc. Maintain complete, accurate, legible, neat, organized, up-to-date records/logs/files, Assure the accuracy of all tests performed by adhering to the Laboratory's Standard Operating Procedures Perform routine and advanced equipment maintenance Contribute to the upkeep and safety View the Kenneth Offit Lab page for Ann Maria. Of these fingernail or toenail Dr. More than 2 decades after the discovery of genetic variants conferring substantial risks for breast, ovarian, prostate, colon, and other malignancies, and despite advances in DNA sequencing technologies, it has become increasingly clear that the promise of genomics as a tool for cancer prevention has yet to be realized. Memorial Sloan Kettering Cancer Center (MSK) is one of the world’s premier cancer centers, committed to exceptional patient care, leading-edge research, and superb educational programs. Hamilton, Michael F. Kenneth Offit is Chief of the Clinical Genetics Service at Memorial Sloan Kettering Cancer Center, a Member of the Program in Cancer Biology and Genetics at the Sloan Kettering Institute, and a Professor of Medicine and Public Health at the Weill College of Medicine of Cornell University. He provides diagnostic and treatment services for patients suffering from all types of cancer. Kenneth Offit is an oncologist in New York. 05) in opposite directions between luminal- and non-luminal subtypes. The lab is currently utilizing large-scale next generation sequencing to understand the role of View the Kenneth Offit Lab page for Former Lab Members. “It opens a powerful window into the inherited origins of a person’s cancer. Blood was drawn following confirmation of Covid-19 positivity. Kenneth Offit is an oncologist in New York, NY and is affiliated with multiple hospitals in the area, including Memorial Sloan Kettering Cancer Center and Mount Sinai Morningside. We seek a highly organized and motivated laboratory technician to work in an academic research laboratory in New York City. Affiliation; Publications; Background; Contact; Other; Phone +1 212 639 5851 Professor of Population Health Sciences, Aug 9, 2022 · Conception and design: Kenneth Offit, Catherine M. Five loci showed associations (P <0. Kenneth Offit, MD, MPH Chief, Clinical Genetics Service; Robert and Kate Niehaus Chair in Inherited Cancer Genomics; Vice Chair, Academic Affairs Department of Medicine Kelsey Breen, MS, MSc, CGC Lead Genetic Counselor Clinical Genetics Service Department of Medicine KEYNOTE SPEAKER Combined Department of Medicine and Department of Mar 3, 2014 · Fergus J. Guidelines are available for variant classification; however, interpretation of these guidelines by laboratories and providers may The current and future applications of genomics to the practice of preventive oncology are being impacted by a number of challenges. They accept 30 insurance plans including Medicare and Medicaid, and telehealth appointments. , M. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an View the Kenneth Offit Lab page for Yelena Kemel. Cancer geneticist Kenneth Offit focuses on gene characterization; genetic and epidemiologic studies of cancer-predisposing alleles; and the therapeutic, prognostic, and psychosocial translation of these findings. P. Phone: (212) 639-2000 and 43 years of experience. Kenneth Offit specializes in Medical Oncology, with a special focus on Hereditary Cancer, Genetic Testing and Lymphoma. View the Kenneth Offit Lab page for Pragna Gaddam. Professor of Population Health Sciences; Professor of Epidemiology in Pathology and Laboratory Medicine; rmt4001@med. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an Kenneth Offit (born February 19, 1955) is an American cancer geneticist and oncologist known for his discoveries with respect to the genetic bases of breast, colorectal, and lymphoid cancers. The database is open sourced, but as Dr. Stadler Sep 5, 2017 · “At the time a person is diagnosed with advanced cancer, we have a vital opportunity to conduct comprehensive genetic testing,” says Kenneth Offit, head of the Niehaus Center, Chief of MSK’s Clinical Genetics Service, and co-senior author of the new study, which was published in the Journal of the American Medical Association (). Mark E. View the Kenneth Offit Lab page for Kenneth Offit. Our research focuses on the identification of novel cancer-susceptibility genes using genomic technologies. These include rapid advances in genomic science and technology that allow massively parallel sequencing of both tumors and the germline, a diminishing of intellectual … Oct 31, 2023 · Kenneth Offit, MD PHILADELPHIA – The Basser Center for BRCA at the Abramson Cancer Center of the University of Pennsylvania, the world’s first comprehensive center aimed at advancing research, treatment, and prevention of BRCA-related cancers, has announced Kenneth Offit, MD, MPH, Memorial Sloan Kettering Cancer Center (MSK) as the recipient of the 2023 Basser Global Prize. Jude group led by physician-scientist Charles Mullighan to address the question. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an View the Kenneth Offit Lab page for Noah Kauff. The lab has a track record in discovery of germ line mutations in cancer and novel loci using genome-wide association studies. Jul 7, 2013 · Gene Patents. This provider has 43 years of experience and is affiliated with Memorial Sloan Kettering Cancer Center. Clinical Genetics Service, Department of Medicine, Memorial Kenneth Offit, et al. View the Kenneth Offit Lab page for Kaitlyn Tkachuk. Kenneth Offit, who is serving on the study’s executive committee, told JTA earlier this month. Cancer geneticist Kenneth Offit focuses on gene characterization; genetic and epidemiologic studies of cancer-predisposing alleles; and the therapeutic, prognostic, and psychosocial translation of these findings. 2009;101:973–975. More About The Kenneth Offit Lab. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an The Clinical Cancer Genetics Research Lab (CGRL) focuses on the discovery and functional characterization of inherited genetic variations that influence the risk of cancer. Lab Head. Overview; Bioinformatics Specialist Kenneth Offit, MD, is chief of the Clinical Genetics Service at Memorial Sloan-Kettering Cancer Center, a member of the Program in Cancer Biology and Genetics at the Sloan- Kettering Institute, and a professor of medicine and public health at the Weill College of Medicine of Cornell University. Levine said. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an View the Kenneth Offit Lab page for Kasmintan (Intan) A. Vijai Joseph Associate Attending Geneticist; Director of Bioinformatics, Niehaus Center. View the Kenneth Offit Lab page for Bioinformatics Specialist. Associate Attending Geneticist; Director of Bioinformatics, Niehaus Center. Mar 13, 2018 · “We think it’s important because it will save lives,” Dr. The BRCA gene is found in all humans, but mutations can cause it to function improperly and increase the risk of developing certain cancers: breast and ovarian in women, reast and May 1, 2020 · INTRODUCTION. , Regulation of Laboratory-Developed Tests in laboratory developed in vitro diagnostic tests , choosing not to “ enforce[] requirements 2023 Basser Global Prize Winner - Kenneth Offit, MD, MPH Kenneth Offit, MD, MPH, Memorial Sloan Kettering Cancer Center (MSK), is the recipient of the 2023 Basser Global Prize. cornell. Jun 6, 2023 · Introduction. Aug 1, 2024 · Kenneth Offit 5. Kenneth Offit is Chief of the Clinical Genetics Service at Memorial Sloan Kettering Cancer Center, a Member of the Program in Cancer Biology and Genetics at the Sloan Kettering Institute, incumbent of the Robert and Kate Niehaus The Clinical Cancer Genetics Research Lab (CGRL) focuses on the discovery and functional characterization of inherited genetic variations that influence the risk of cancer. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an Willis J, Mukherjee S, Orlow I, Viale A, Offit K, Kurtz R, Olson S, Klein R. The individual will be a core team member working with other faculty, students and postdocs and will be responsible for analysis of large scale cancer germline and tumor next generation sequencing and microarray data sets. Oct 17, 2019 · View the Kenneth Offit Lab page for Computational Genetics Fellow. Klus, Judit Börcsök, Zsofia Sztupinszki, Timothy Hanlon, Miklos Diossy, Laura Vizkeleti, Dag Rune Stormoen, Istvan Csabai, Helle Pappot, Joseph Vijai, Kenneth Offit, Thomas Ried, Nilay Mar 13, 2018 · Dr. The epithelial cases differentiate into five main histological subtypes (“histotypes”), including high-grade serous carcinomas (HGSC), which is the most frequent subtype [], low-grade serous carcinomas (LGSC), mucinous, endometrioid and clear cell Dr. Research in The Kenneth Offit Lab focuses on the discovery and characterization of novel cancer predisposing genes in humans, including both common and rare variants. Nov 21, 2017 · There has been no indication to test for <i>BRCA1/2</i> in children (with the rare exception of Fanconi anemia) as screening begins in adult years and there is a potential to induce anxiety related to adult-onset cancers. Kenneth Offit (born February 19, 1955) is an American cancer geneticist and oncologist known for his discoveries with respect to the genetic bases of breast, colorectal, and lymphoid cancers. Dr. (2012) A replication study and genome-wide scan of single-nucleotide polymorphisms Kenneth Offit, M. Offit hopes that ongoing research will determine what percentage of childhood ALL patients have the PAX5 mutation. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an View the Kenneth Offit Lab page for Kenneth Offit: Publications. He is also Professor of Medicine and Public Health at Weill Medical College of Cornell University, and Vice Chairman of the Program in Prevention, Control and Population Research at MSKCC. Kenneth Offit Lab Head. However, in the setting of pediatric cancer, with increasing utility and frequ … Oct 1, 2008 · Genetic analysis showed that the tumor cells have a mutation in the gene for the signaling molecule JAK2. He received clinical training in medical oncology and had laboratory experience in cancer genetics at the Memorial Sloan-Kettering View the Kenneth Offit Lab page for Zsofia K. Journal of clinical oncology 23 (2), 276-292, 2005. We identified 32 novel susceptibility loci (P < 5. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an View the Kenneth Offit Lab page for Michael Walsh. [1] Associate Director of Laboratory Operations; Head, Functional Genomics, Niehaus Center His laboratory currently focuses on utilizing genomic approaches to discover novel mechanisms associated with increased risk for common malignancies, or which modify the risks of known hereditary predispositions. Kenneth Offit, et al. Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. View the Kenneth Offit Lab page for Christina Tran. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc. , Regulation of Laboratory-Developed Tests in laboratory developed in vitro diagnostic tests , choosing not to “ enforce[] requirements Sep 9, 2013 · Preventing Future ALL in Affected Families. Nathanson, 2 and Kenneth Offit 3 Fergus J. View the Kenneth Offit Lab page for Lauren Jacobs. Vijai Joseph. 05). Genomic advances have facilitated hereditary cancer risk prediction and improved molecular diagnostics,1 resulting in a panoply of tests for inherited disease risk and presymptomatic disease detection (Table 1). View the Kenneth Offit Lab page for Research Technician & Internships. Reviews of Dr. Laboratory of Human Carcinogenesis Feb 22, 2022 · Alexandra Joyner, PhD, Member and Developmental Biologist at Sloan Kettering Institute (SKI), Ming Li, PhD, Member and Immunologist at Sloan Kettering Institute (SKI), and Kenneth Offit, MD, Chief of MSK’s Clinical Genetics Service and the Robert and Kate Niehaus Chair in Inherited Cancer Genomics, were elected to the 2021 class of American Association for the Advancement of Science (AAAS The following author has made extensive contributions to the literature relative to gene curation and genetic testing: Kenneth Offit, The following authors are an employee, trainee or consultant for a commercial laboratory that offers hereditary cancer panel testing: Matthew J. View the Kenneth Offit Lab page for Kasmintan (Intan) A. I am a molecular biologist who focuses on investigating the underlying genetic changes and cellular mechanisms leading to oncogenesis, with a specific focus on the role of DNA repair pathways. ” 8 A patent holder may grant permission to others to use the work, such as through licensing. Candidates with a research background and recent Masters Degree are preferred; Biology or Bioinformatics majors with at least an undergraduate degree Jan 1, 2023 · Kenneth Offit Patents, Royalties, Other Intellectual Property: Patent pending on therapeutic applications of targeting ERCC3 mutations in cancer. Ferber is employed at clinical molecular lab at Mayo Medical Dec 3, 2024 · Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan Kenneth Offit. He is a graduate of Princeton University, the Kenneth Offit Lab Head Vijai Joseph Associate Attending Geneticist; Director of Bioinformatics, Niehaus Center Mark E. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an appointment. JE Garber, K Offit. Kenneth Offit, who heads the Clinical Genetics Service and is a member of Sloan Kettering Institute’s Cancer Biology and Genetics Program, is honored with this year’s ASCO – American Cancer Society Award and Lecture, which distinguishes noteworthy contributions to the prevention and management of cancer. Memorial Sloan Kettering Cancer Center,&nbsp; New York City Dr. Walsh, Steven M. My MSKCC colleagues and I also published the View the Kenneth Offit Lab page for Yvonne Bombard. [1] He is currently Chief of the Clinical Genetics Service and the Robert and Kate Niehaus Chair in Inherited Cancer Genomics at Memorial Sloan Kettering Kenneth Offit, MD, MPH is Chief of the Clinical Genetics Service in the Department of Medicine at Memorial Sloan Kettering Cancer Center (MSKCC). The lab has a good track record in discovery of germ line mutations in cancer and novel loci using genome-wide association studies. Dec 8, 2015 · “The Niehaus Center will take cancer risk assessment and early detection at MSK to an exciting new level,” says Kenneth Offit, Chief of MSK’s Clinical Genetics Service, who is leading the new center. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an View the Kenneth Offit Lab page for Zarina Fnu. He received his medical degree from Harvard Medical School and has been in practice 35 years. The “duty to warn” a patient’s family members about hereditary disease risks. Willis J, Olson S, Orlow I, Mukherjee S, McWilliams R, Kurtz R, Klein R. 884: 2005: View the Kenneth Offit Lab page for Tomas Kirchhoff. Sharkey, Xiaohan Wu, Jada G. Mar 18, 2008 · The recent marketing of "at home" genomic tests for disease risk may be premature, according to Dr. Couch 1 Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA. Memorial Sloan Kettering Cancer Center. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an May 22, 2013 · View the Kenneth Offit Lab page for Kenneth Offit: Featured News. Feb 11, 2019 · “One of the nice features of the mobile app is that users can elect to receive notifications when classifications change in the future,” says Kenneth Offit, Chief of MSK’s Clinical Genetics Service and a member of BRCA Challenge, the international group that created the BRCA Exchange. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an appointment Cancer geneticist Kenneth Offit focuses on gene characterization; genetic and epidemiologic studies of cancer-predisposing alleles; and the therapeutic, prognostic, and psychosocial translation of these findings. Kenneth Offit says a new study on BRCA mutations in Ashkenazi Jews will help save lives and contribute lessons for future medical testing. Kenneth Offit is an oncologist in New York, Regulation of Laboratory-Developed Tests in Preventive Oncology: Emerging Needs and Opportunities. Aurel Prosz#, Haohui Duan#, Viktoria Tisza#, Pranshu Sahgal, Sabine Topka, Gregory T. Offit’s work identified the most common mutation associated with an increased risk of breast, ovarian, and prostate cancer among individuals of Ashkenazi Jewish ancestry. Research Overview Featured News Publications Open Positions. Kenneth Offit, MD, is a specialist in oncologist who treats patients in New York, NY. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an Kenneth Offit, MD MPH Dr. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an View the Kenneth Offit Lab page for Christopher Manschreck. View the Kenneth Offit Lab page for Sita Dandiker. Lipkin, Michele Caggana Administrative support: Kenneth Offit, Sita Dandiker Provision of study materials or patients: Dina Green, Magan Trottier Oct 10, 2024 · Genomic DNA was isolated from peripheral blood, saliva, and fresh-frozen, paraffin-embedded tissues as described previously. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an The Kenneth Offit Lab. edu (646 . My research is focused on the best ways to use genetic information to improve outcomes of patients with or at risk for hereditary cancers of all types. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an View the Kenneth Offit Lab page for Hayley Smith. Current estimates suggest that the gene mutation is quite rare, and Memorial Sloan Kettering will again team with the St. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an View the Kenneth Offit Lab page for Karen Cadoo. Robson Chief, Breast Medicine Service; Lead, Inherited Breast Cancer Genomics, Niehaus Center Zsofia K. Stadler Lead, Inherited Gastrointestinal Cancer Genomics, Niehaus Center People Kenneth Offit, MD Principal Investigator: Kenneth Offit | Research in the laboratory focuses on the discovery and characterization of novel cancer predisposing genes in humans, including both common and rare variants. Bio Sketch Kenneth Offit received his MD and MPH in 1981 from the Harvard Medical School and the Harvard School of Public Health. 1093/jnci/djp184. Massively parallel sequencing allows simultaneous testing of multiple genes associated with cancer susceptibility. Skip to main content Ready to start planning your care? Call us at 833-347-1665 to make an View the Kenneth Offit Lab page for Mark E. Stadler. The lab conducts studies to describe phenotype, penetrance, modifying effect, and clinical outcomes associated with germline genetic alterations in patients Experience: Memorial Sloan Kettering Cancer Center · Location: New York · 500+ connections on LinkedIn. The Clinical Cancer Genetics Research Lab (CGRL) focuses on the discovery and functional characterization of inherited genetic variations that influence the risk of cancer. Breast cancer single-nucleotide polymorphisms: statistical significance and clinical utility. Robson Chief, Breast Medicine Service; Lead, Inherited Breast Cancer Genomics, Niehaus Center. “These laboratory-based insights have incredible value,” Dr. Skip to main content Ready to start planning your care? Call us at 833-347-1665 to make an Job Description Perform technical duties related to the supporting of the cell and molecular microbiology protocols. Offit points Dr. Oct 13, 2021 · Laboratory-confirmed patients with Covid-19 who were hospitalized between January and April 2020 in four tertiary hospitals in the Republic of Korea were approached for consent to this study. 9, 10 For DNA isolation from nail clippings, ten fingernails or ten toenails were collected from the patient and submitted to the laboratory as long thin strands in a dry sterile container. Zsofia K. J Natl Cancer Inst. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an View the Kenneth Offit Lab page for Xiaoni Gao. Jan 1, 2023 · Kenneth Offit 1 2 , Catherine M Sharkey 3 , Dina Green 1 , Xiaohan Wu 4 , Magan Trottier 1 , Jada G Hamilton 1 2 , Michael F Walsh 1 2 , Sita Dandiker 1 , Sami Belhadj 1 , Steven M Lipkin 2 , Thelma Alessandra Sugrañes 5 , Michele Caggana 6 , Zsofia K Stadler 1 2 Dr. My research focuses on defining genetic factors that cause an increased susceptibility to cancer. Rooted in the US Constitution, a patent is “the grant of a property right to an inventor, issued by the United States Patent and Trademark Office (USPTO), generally for a period of 20 years from the filing date of the inventor's patent application. Couch, 1, * Katherine L. 2 From the regulatory perspective, cancer predictive or diagnostic assays are considered Laboratory-Developed Tests (LDTs). Schrader. View the Kenneth Offit Lab page for John Sullivan. Lipkin, Thelma Alessandra Sugrañes , Michele Caggana, Zsofia K. (2014) Genome-wide analysis of the role of copy-number variation in pancreatic cancer risk. Sharkey, Dina Green, Xiaohan Wu, Magan Trottier, Jada G. 1 Fewer than 1 in 5 individuals with a family history of Kenneth Offit , MD, MPH. Skip to main content Ready to start planning your care? Call us at 833-347-1665 to make an Feb 1, 2006 · NPI Profile for Kenneth Offit internist in 1275 York Ave New York, Ny 10021. Walsh, Sita Dandiker, Sami Belhadj, Steven M. Offit K. This finding allows his laboratory to focus on JAK2 activity and the pathway it regulates to improve therapies for patients with these disorders. View Vijai Joseph’s profile on LinkedIn, a professional community of 1 billion members. Skip to main content Ready to start planning your care? Call us at 833-347-1665 to make an View the Kenneth Offit Lab page for The Kenneth Offit Lab: Research Overview. Kenneth Offit, MD, MPH, Chief of the Clinical Genetics Service at Memorial Sloan Kettering Cancer Center (MSKCC). Front Genet , 5, 29. Ovarian cancer can be classified based on tumour origin into epithelial (~90% of all cases []), sex cord/stromal and germ cell. The cloning of the breast cancer susceptibility genes BRCA1 and BRCA2 nearly two decades ago helped set in motion an avalanche of research exploring how genomic information can be optimally applied to identify and clinically care for individuals with a high risk of developing cancer. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make Kenneth Offit. Taxonomy 207RX0202X PECOS Enrolled Accepts: Medicare and Medicaid View the Kenneth Offit Lab page for Ryan Kopp. Offit The Kenneth Offit Lab. Stadler View the Kenneth Offit Lab page for Lab Members. [Google Scholar] Offit K, Groeger E, Turner S, Wadsworth EA, Weiser MA. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an View the Kenneth Offit Lab page for Sohela Shah. View the Kenneth Offit Lab page for Functional Postdoctoral Fellow/Senior Research Scientist in Cancer Biology and Genetics. Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma. Kenneth Offit. Oct 7, 2014 · Kenneth Offit Department of Medicine and Public Health, Weill Cornell Medical College, Cornell University, 445 East 69th Street, New York, 10021, NY, USA Authors 2024. Diagnosis and treatment of ercc3-mutant cancer US20210137850A1 View the Kenneth Offit Lab page for Nisha Pradhan. (Courtesy of Memorial Sloan Kettering Cancer Center) May 22, 2013 · The ASCO-American Cancer Society Award to Dr. doi: 10. Regulation of Laboratory-Developed Tests in Preventive Oncology: Emerging Needs and Opportunities Kenneth Offit, Catherine M. org. We are specifically interested in helping to determine the genetic basis of “sporadic” cancers in young adults and children. Chief, Breast Medicine Service View the Kenneth Offit Lab page for Sabine Topka. Kenneth Offit Professor of Medicine. My research team identified the most common mutation associated with an increased risk of breast and ovarian cancer among individuals of Ashkenazi Jewish ancestry. He practices primarily in New York, NY, and is affiliated with Memorial Sloan Kettering Cancer Center. Klus, Judit Börcsök, Zsofia Sztupinszki, Timothy Hanlon, Miklos Diossy, Laura Vizkeleti, Dag Rune Stormoen, Istvan Csabai, Helle Pappot, Joseph Vijai, Kenneth Offit, Thomas Ried, Nilay 2024. H. Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an View the Kenneth Offit Lab page for Ying Liu. Robson. Offit. vdl pflc rnq omupf qlpr plms hedssgwc zusf qav uwjx